Endocrine Abstracts

Objective: To assess the impact of genetic polymorphisms associated with increased cardiovascular risk on the lipid profile in healthy postmenopausal women.Methods: The study population consisted of 84 women between 49–69 years who had been menopausal for at least one year. The genetic polymorphisms examined were the following: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenotetrahydrofolate reductase ala222val, Apolipoprotein B arg350...

Objective: To assess the interrelation of the MTHFR ala222val polymorphism, correlated with increased rates of cardiovascular disease, with indices of androgenicity in healthy postmenopausal women.Methods: The population of this cross-sectional study consisted of 84 healthy women who had been menopausal for at least one year. The examined polymorphism was Methylenetetrahydrofolate reductase ala222val, while the hormonal assays included Testosterone, Sex ...

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.Design: Randomized, double-blinded study.Patients: One hundred healthy postmenopausal women.Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2</...

Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP),...